Synthesis, characterization and evaluation of antioxidant, anticancer and toxicity properties of silver nanoparticles synthesized from Syzygium aromaticum

Background: Syzygium aromaticum, also known as clove, and its essential oil has already been proved to have antioxidant, anti-inflammatory anticancer properties. Clove is used in various foods owing potent antimicrobial antioxidant Essential extracted from clove traditional medicine for treating ailments. Methods: In silico analyses of phytocompounds aromaticum namely eugenol, B-caryophyllene, gallic acid, crategolic kaempferol, quercetin, cinnamaldehyde, oleanolic acid were docked with three apoptotic proteins involved breast cancer, BCL-2, BAX APAF-1 using AUTODOCK. addition, flower bud extract was the synthesis AgNPs (silver nanoparticles). The synthesized clove-silver nanoparticles then characterized techniques such Ultraviolet-visible spectrophotometry, FTIR, FESEM-EDX, DLS zeta potential determine particle size, shape, crystalline structure, stability CL-AgNPs tested MCF-7 cell lines. Results: analysis predicted that phytochemicals good interactions apoptosis related cancer. vitro assay confirmed cytotoxic effect on cancer cells line IC50 value 58.64 µg/ml. Conclusion: activity supports study by proving active between target hence possess property. Further research needed consider a novel drug